Midlife is a time of significant hormonal change, and for many women it can also bring unexpected shifts in mood, anxiety, or low emotional resilience. Perhaps a relapse of PMS-like symptoms, sinking motivation or low mood. The research suggests that if you have a history of depression, these changes may be more intense during perimenopause, as fluctuating oestrogen levels, brain chemistry, and stress hormones interact in complex ways. Understanding the link between perimenopause and depression can help explain what’s happening in your body and highlight why a holistic, integrative approach is so important for supporting mental health during this transition.